To present a long term follow-up of a patient with crystalline keratopathy of both eye’s diagnosed with monoclonal gammopathy of undetermined significance (MGUS). Full Thickness corneal transplantation was performed because of significant life threatening visual loss. Recurrence has occurred within a year. Introducing of the term Monoclonal Gammopathy of Ocular Significance is justified in MGUS patients who develop severe crystalline keratopathy with vision impairment. Future therapeutic options to eradicate the plasma clone responsible for the circulating M protein could potentially reduce the risk of recurrence after corneal transplantation.

Dr. Siamak Nobacht, MD, FEBOphth.
Ophthalmologist, director of anterior segment, Cataract & Corneal surgery.
Department of Ophthalmology
Radboud University Medical Centre, Nijmegen, The Netherlands
Postbus 9101
6500 HB Nijmegen, The Netherlands