Several alterations in the gastrointestinal tract which occur after appendectomy or cholecystectomy have been suggested to raise the risk of developing colorectal carcinoma. Given the frequency that these procedures are performed, we sought to determine whether a history of either cholecystectomy or appendectomy increased the risk of a future colorectal carcinoma. Firstly, we determined the number of patients with a history of appendectomy and cholecystectomy who developed colorectal carcinoma between January 2018 and February 2021, as well as the latency time between the two diseases. Secondly, we carried out a data-collection spanning 15 years after the primary surgery (January 2005 – December 2006). The post-cholecystectomy state is significantly more frequently observed in patients treated for colorectal carcinomas (both male and female), especially among those who developed right-sided or left-sided colon cancer, as opposed to anorectal cancer (p=0.53). However, the time elapsed between the two diseases is 20-25 years, which appears to be markedly long regarding such a multifactorial disease as the colorectal carcinoma. No similar extra risk was observed among patients having appendectomy. Secondly, we found no extra risk during the first 15 years after cholecystectomy. Although a statistically higher risk of colon cancer is observed after the removal of the gallbladder, but the latency time is long. Thus, cholecystectomy may not be an independent risk factor for colorectal carcinogenesis. Altogether, the patient is not exposed to a higher risk of colorectal carcinogenesis after having cholecystectomy.
Dr.Miklós Mándi MD, PhD is working as a general surgeon and adjunct professor on the Surgery Unit of the Bajcsy-Zsilinszky Hopsital since 2008. He obtained the speciality in General Surgery in 2012. Parallel to his studies as General Surgeon he received the PhD degree in the same year in the field of Biochemistry for “Studies on Cyclophilin-D and NAADP on Ca2+-mediated events” on Semmelweis University. Nowadays, along with his clinical work, Miklós Mándi continues his scientific work in the field of Surgery. He has a wife and 2 children.