The gold nanoparticles surface was modified by thioglycolic acid ligand and their surface was coated by the chitosan-grafted-poly(N-vinylcaprolactam) (chitosan-g-PNVCL) copolymer. The cisplatin anticancer drug was loaded into the synthesized nanocarriers and its performance was investigated for the treatment of MCF-7 breast cancer cells in vitro. The lower critical solution temperature (LCST) of PNVCL/chitosan and PNVCL/chitosan coated gold nanoparticles were found to be 38 and 39°C, respectively. The cisplatin loading efficiency, cisplatin release from nanoparticles at different temperatures and pH values as well as the pharmacokinetic studies were examined. The maximum cisplatin release from nanoparticles was achieved at T>LCST (42 °C) and pH of 5. The Korsemeyer-Peppas model was best described the cisplatin release from nanoparticles. The maximum MCF cell death was found to be 92% using cisplatin loaded gold/TGA/chitosan-g-PNVCL nanoparticles under an induction heating system.
Dr. Mahshid Nikpour Nezhati received her PhD in organic chemistry in 2003. Since then, she has been a faculty member at central branch of Azad University in Tehran/Iran. Her team and she successfully performed several research projects in synthesis and application of magnetic and non magnetic nanoparticles as suitable adsorbents with an acceptable potential for coating with smart polymers and perform controlled absorption and release of drugs, especially anti cancer drugs. The results of these projects have been published, presented at international congresses or patented. My current research focuses on the synthesis and application of polymeric nano carriers, which are able to controlled absorption and release of the anticancer drugs in different conditions.