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Abstract: Enhancing therapy sensitivity is a big challenge in oncology. Based on genetic and epigenetic modifications altering intra- and extracellular processes, glioblastoma (GBM) belongs to the group of tumor entities with unmet need, is highly refractory to...
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Abstract: The field of cancer immunotherapy has expanded rapidly in the past few years, with many new approaches entering the clinic for T cell mediated killing of tumors. Several of these clinical approaches involve the exploitation of a CD8 + T cell response against...
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Abstract: Carbon dots (CDs) with size less than 10 nm have recently triggered great attention in the research of material science and biomedical engineering due to their unique properties such as small size, excellent photoluminescence (PL), high water-dispersity,...
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Abstract: Thrombotic risk should be evaluated regularly in different clinical settings of cancer patients. Thromboprophylaxis with low molecular weight heparin (LMWH), being able to be complemented with mechanical means, or the alternative use of a inferior vein cave...
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Abstract: Emerging reports suggest Delta-like-ligand 4 (DLL4) is a promising target to augment the effects of VEGF inhibitors. Simultaneous blockade of VEGF/VEGFR and DLL4/Notch signaling pathways leads to more potent inhibition of tumor progression by a synergic...
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Abstract: Bispecific antibodies that interact with tumor antigens on cancer cells and activating receptors on immune cells offer an innovative immunotherapy approach. REGN4018 is a bispecific antibody that binds both Mucin 16 (MUC16), a glycoprotein that is highly...
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Abstract: The Her receptor tyrosine kinase family has four members, namely Her-1 (EGFR or ErB1), Her-2 (Neu or ErbB2), Her-3 (ErB3) and Her-4 (ErB4). Activation of the kinases results in intracellular signalling events leading to some oncogenic and aggressive...
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Abstract: Aneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most solid tumors. Such aneuploidies result in tumor specific genomic imbalances, which emerge in premalignant precursor lesions. Moreover, increasing levels of chromosomal...
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Biography: Dr. Russel J. Reiter is Professor of Cell Biology in the Department of Cell Systems and Anatomy at the UT Health, San Antonio, Texas, USA, In addition to his Ph.D. degree, Dr. Reiter has received three honorary M.D. degrees and one honorary D.Sc. degree...
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Abstract: Skin aging is determined not only by genetic aspects but mainly by environmental factors and the lifestyle of each individual. Solar UV-radiation, nicotine and alcohol consumption can cause free radical formation in human skin. In small concentrations free...
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Abstract: I have been performing living donor liver transplantation (LDLT), which is the only way to save the life of patients with end-stage liver disease. In June 1990, we performed the first LDLT that case was the first successful case in Japan. The patient remains...
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Abstract: Background: The use of complementary and alternative medicine has increased worldwide over the past decade. The aim of this study was to evaluate a possible influence of homeopathy on global health status and subjective wellbeing when used as an add-on to...
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My family’s journey in managing my husband’s battle with Stage IV Colorectal Cancer has been an eye-opener to the inequities in Healthcare, not only amongst the insured and uninsured but also within the insured subgroup. It has motivated us to develop ways to narrow...
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Abstract: Background: Primary and secondary breast angiosarcoma is a rare and aggressive malignancy with limited published literature. Optimal management is mostly based on expert opinion. Our study aims to describe a single institution experience with breast...
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Research Field: Shoshan-Barmatz laboratory focuses on VDAC1, a protein located in the outer mitochondrial membrane that acts as a gatekeeper of mitochondrial functions, including metabolism and energy production. VDAC1 serves as a hub protein, interacting with various...
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Abstract: Hematopoietic stem cell transplantation (HSCT) is effective for hematological disorders. Its success partly depends on the efficacy of the conditioning regimen. To identify efficacious regimens, we exposed cells to various drug combinations, analyzed their...
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Abstract: Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD). On irradiation with visible light, PpIX...
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Abstract: Great advances have taken place in the understanding and treatment of pediatric malignant tumors for the past a few decades. However, challenges still exist such as lack of efficient treatments for certain tumors and the side effects and impact of the...
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Abstract: CXCL4 is mainly produced by activated platelets, but certain somatic cells and cancer cells also express CXCL4. However, the physiological function of non-platelet-derived CXCL4 is unclear. Previously we reported that CXCL4 produced by cancer cells...
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Abstract: The synthesis of novel homodimers is reported based on the anilinoisoquinolinequinone scaffold. In these twin-drug derivatives, two units of the anilinoquinone pharmacophores are linked through a methylene spacer. The formation of dimers was achieved by...
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Abstract: Social isolation is an important social determinant that impacts health outcomes and mortality among patients. The National Academy of Medicine recently recommended to document social isolation in electronic health records(EHR). However, social isolation...
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Abstract: The advent of nanotechnology has opened up enormous opportunities in the bio-sensing area, allowing the fabrication of constructs that are small enough to be targeted in the interior of single living cells and their intracellular compartments. Nanotechnology...
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Abstract: Cancer is still a leading cause of death worldwide. Despite the improvements achieved in cancer therapy the outcome is still partially ineffective against different cancer types. Therefore, there is dramatic need to develop novel treatment modalities. Among...
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Abstract: The effectiveness of the synergеtic approach is based on the ability to transfer the results of one science (e.g. physics), being more “simple” and accurate due to omitting many details that can be considered inessential, to objects of other...
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Abstract: Background: Hepatic ischemia reperfusion (IR) injury is an inevitable risk after liver transplantation, characterized by a plethora of events leading to hepatocellular injury. Indeed, hepatic IR injury triggers high-mobility group box protein B1 (HMGB1)...
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Abstract INTRODUCTION: Cutaneous cystic lesions have broad differentials ranging from common benign entity to rare malignant lesions. Clinical evaluation of the lesion is the key to differentiation, as some rare malignant entities may simulate benign lesions. A high...
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Abstract: Diabetes mellitus potentiates the risk of breast cancer. We have previously described the pro-tumorigenic effects of advanced glycation end-products (AGEs) on estrogen receptor (ER)-negative MDA-MB-231 breast cancer cell line mediated through the receptor...
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Abstract: The gold nanoparticles surface was modified by thioglycolic acid ligand and their surface was coated by the chitosan-grafted-poly(N-vinylcaprolactam) (chitosan-g-PNVCL) copolymer. The cisplatin anticancer drug was loaded into the synthesized nanocarriers and...
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