by Cancer & Oncotherapy | May 30, 2022
Abstract: Skin cancer is the most common cancer in the United States and among Caucasians worldwide, with more people diagnosed each year than all other cancers combined. Basal cell cancer is the most common form with an estimated 4.3 million cases diagnosed annually,...
by Cancer & Oncotherapy | Apr 14, 2022
Abstract: Emerging reports suggest Delta-like-ligand 4 (DLL4) is a promising target to augment the effects of VEGF inhibitors. Simultaneous blockade of VEGF/VEGFR and DLL4/Notch signaling pathways leads to more potent inhibition of tumor progression by a synergic...
by Cancer & Oncotherapy | Apr 14, 2022
Abstract: Bispecific antibodies that interact with tumor antigens on cancer cells and activating receptors on immune cells offer an innovative immunotherapy approach. REGN4018 is a bispecific antibody that binds both Mucin 16 (MUC16), a glycoprotein that is highly...
by Cancer & Oncotherapy | Apr 14, 2022
Abstract: The Her receptor tyrosine kinase family has four members, namely Her-1 (EGFR or ErB1), Her-2 (Neu or ErbB2), Her-3 (ErB3) and Her-4 (ErB4). Activation of the kinases results in intracellular signalling events leading to some oncogenic and aggressive...
by Cancer & Oncotherapy | Apr 14, 2022
Abstract: Enhancing therapy sensitivity is a big challenge in oncology. Based on genetic and epigenetic modifications altering intra- and extracellular processes, glioblastoma (GBM) belongs to the group of tumor entities with unmet need, is highly refractory to...
by Cancer & Oncotherapy | Jan 26, 2022
Abstract There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, the molecular mechanisms underpinning these inhibitory actions have been proposed. What is rather perplexing, however, is...
by Cancer & Oncotherapy | Jan 26, 2022
Abstract: Background: The use of complementary and alternative medicine has increased worldwide over the past decade. The aim of this study was to evaluate a possible influence of homeopathy on global health status and subjective wellbeing when used as an add-on to...
by Cancer & Oncotherapy | Jan 26, 2022
Abstract Aneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most solid tumors. Such aneuploidies result in tumor specific genomic imbalances, which emerge in premalignant precursor lesions. Moreover, increasing levels of chromosomal...
by Cancer & Oncotherapy | Feb 20, 2020
Abstract My family’s journey in managing my husband’s battle with Stage IV Colorectal Cancer has been an eye-opener to the inequities in Healthcare, not only amongst the insured and uninsured but also within the insured subgroup. It has motivated us to develop ways to...
by Cancer & Oncotherapy | Feb 20, 2020
Abstract: Background: Primary and secondary breast angiosarcoma is a rare and aggressive malignancy with limited published literature. Optimal management is mostly based on expert opinion. Our study aims to describe a single institution experience with breast...
by Cancer & Oncotherapy | Dec 2, 2019
Research Field: Shoshan-Barmatz laboratory focuses on VDAC1, a protein located in the outer mitochondrial membrane that acts as a gatekeeper of mitochondrial functions, including metabolism and energy production. VDAC1 serves as a hub protein, interacting with various...
by Cancer & Oncotherapy | Dec 2, 2019
Abstract: Hematopoietic stem cell transplantation (HSCT) is effective for hematological disorders. Its success partly depends on the efficacy of the conditioning regimen. To identify efficacious regimens, we exposed cells to various drug combinations, analyzed their...
by Cancer & Oncotherapy | Dec 2, 2019
Abstract: Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD). On irradiation with visible light, PpIX...
by Cancer & Oncotherapy | Nov 14, 2019
Abstract: Social isolation is an important social determinant that impacts health outcomes and mortality among patients. The National Academy of Medicine recently recommended to document social isolation in electronic health records(EHR). However, social isolation...
by Cancer & Oncotherapy | Nov 14, 2019
Abstract: The effectiveness of the synergеtic approach is based on the ability to transfer the results of one science (e.g. physics), being more “simple” and accurate due to omitting many details that can be considered inessential, to objects of other...
by Cancer & Oncotherapy | Nov 14, 2019
Abstract INTRODUCTION: Cutaneous cystic lesions have broad differentials ranging from common benign entity to rare malignant lesions. Clinical evaluation of the lesion is the key to differentiation, as some rare malignant entities may simulate benign lesions. A high...
by Cancer & Oncotherapy | Nov 14, 2019
Abstract: Diabetes mellitus potentiates the risk of breast cancer. We have previously described the pro-tumorigenic effects of advanced glycation end-products (AGEs) on estrogen receptor (ER)-negative MDA-MB-231 breast cancer cell line mediated through the receptor...
by Cancer & Oncotherapy | Nov 14, 2019
Abstract: The gold nanoparticles surface was modified by thioglycolic acid ligand and their surface was coated by the chitosan-grafted-poly(N-vinylcaprolactam) (chitosan-g-PNVCL) copolymer. The cisplatin anticancer drug was loaded into the synthesized nanocarriers and...
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